news & publications
Farra, Robert, et al. "First-in-human testing of a wirelessly controlled drug delivery microchip." Science Translational Medicine 4.122 (2012): 122ra21-122ra21.
This first-in-human clinical trial evaluated the pharmacokinetic profiles of human parathyroid hormone (hPTH(1–34))delivered by the microchip-based implant versus subcutaneous injections. Results indicated that the release profile of hPTH(1–34) from the microchip-based implant was comparable and bioequivalent to the profile of subcutaneous injections. In addition, patients reported positively when surveyed about their implant experience.
Prescott, James H., et al. "Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device." Nature biotechnology 24.4 (2006): 437-438.
This first-in-animal study evaluated the ability of the microchip-based implant to deliver leuprolide (an analog of a luteinizing hormone-releasing hormone that is marketed for the treatment of prostate cancer and endometriosis) over a 6-month period in dogs. Results supported the feasibility of applying microchip-based implant technology to deliver other therapeutic peptides and proteins. In addition, the study suggested that drug delivery from an array of discrete reservoirs is not restricted to solution-phase drug formulations, and that stability-optimized, solid-phase drug formulations can be packaged and released in vivo.
Grayson, Amy C. Richards, et al. "Multi-pulse drug delivery from a resorbable polymeric microchip device." Nature materials 2.11 (2003): 767-772.
The Microchips Biotech IP portfolio includes both electronically-controlled reservoir implants as well as preprogrammed, non-electronic reservoir-based implants, made of resorbable polymers. This study evaluated the functionality of a biodegradable microchip implant and demonstrated that timed, pulsatile delivery is possible by varying the molecular mass of the membranes covering each reservoir.
Santini, John T., Michael J. Cima, and Robert Langer. "A controlled-release microchip." Nature 397.6717 (1999): 335-338.
MIT Professors Dr. Robert Langer and Dr. Michael Cima published results of the first study demonstrating the ability of a novel reservoir-based microchip implant to electronically release single or multiple chemical substances, on demand.